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Always consult your GP or a registered dietitian before starting supplementation, particularly if you have existing health conditions or take regular medications

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In this pictorial review, we sought to focus on the link between PD and Vit B12 and holistically pinpoint the peculiarities of Vit B12 effect on the molecular, neuropathological and genetic aspects of PD and overview the phenotypic expression, both motor and non-motor, of PD in the light of Vit B12 deficiency

It was initially planned to recruit 20 analyzable patients (who completed the two-treatment periods) to have 80% power to detect, with a two-sided test at 0.05 significance level, an absolute decrease in percentage over total target of 10% under the A-dopamine period compared with the control (oral l-dopa-alone treatment) period, by assuming a standard deviation of 15% and a within-patient correlation of 0.5 to account for the crossover design